Description

AspirinWorks® evaluates 11-dehydrothromboxane B2 in urine — a stable marker linked to thromboxane production and platelet activation.

When aspirin is effective, thromboxane activity should be lower. If thromboxane remains elevated, it may suggest reduced aspirin response (sometimes called “aspirin resistance” or “aspirin non-response”).

Who this is for

This test can be helpful if you:

  • Take daily aspirin (81 mg or 325 mg) for cardiovascular prevention
  • Have a history of:
    • Heart attack, stent, or coronary artery disease
    • Stroke/TIA
    • High Lp(a) or strong family history of early heart disease
  • Want objective confirmation that aspirin is providing the intended benefit
  • Suspect reduced response due to inflammation, medication interactions, or absorption issues

Note: Do not stop aspirin without speaking with your prescribing clinician.

Why it matters

Not everyone responds to aspirin the same way. Factors that can affect aspirin response include:

  • Medication timing and adherence
  • Interactions (example: some NSAIDs can interfere when taken near aspirin)
  • Inflammation / oxidative stress
  • Individual platelet biology

AspirinWorks® can support a more personalized prevention plan — confirming aspirin effect or prompting a discussion about next steps.

Preparation instructions

  • No fasting required