Description
Arthritis refers to inflammation of the joints, leading to symptoms such as pain, stiffness, and swelling. There are many potential causes of arthritis, including autoimmune diseases like rheumatoid arthritis (RA) and lupus. Identifying the underlying cause is essential to guide treatment decisions. This basic panel focuses on essential biomarkers commonly used to screen for autoimmune causes of joint inflammation.
This test serves as a valuable first step in evaluating joint pain and distinguishing between different types of arthritis. Additional testing may be recommended based on clinical findings.
Included Biomarkers and Tests:
Antinuclear Antibody (ANA) Screen with Reflex to Titer and Pattern
- Screens for autoantibodies often present in systemic autoimmune diseases, such as lupus (SLE) and mixed connective tissue disease.
- If positive, the test reflexes to a titer and pattern analysis to provide more diagnostic detail.
C-Reactive Protein (CRP)
- A sensitive inflammatory marker produced by the liver.
- Elevated CRP levels may indicate active joint inflammation or systemic autoimmune activity.
Rheumatoid Factor (RF)
- A key autoantibody associated with rheumatoid arthritis.
- Elevated levels may support the diagnosis of RA, especially in conjunction with symptoms and other lab findings.
Test Preparation:
- Fasting: Not required
- Sample Type: Blood (venipuncture)
Recommended For Individuals With:
- Persistent joint pain or stiffness
- Suspected early rheumatoid arthritis or lupus
- Family history of autoimmune disorders
- Swollen or tender joints without clear cause
Clinical Use Cases:
- Initial screening for autoimmune causes of arthritis
- Supporting early diagnosis of rheumatoid arthritis or lupus
- Evaluating inflammation as a source of joint symptoms
- Guiding next steps in diagnostic workup or specialist referral
