Description
HLA Genetic Testing for Autoimmune Addison’s Disease Susceptibility
Addison’s disease, also known as primary adrenal insufficiency, can occur when the immune system attacks and progressively damages the adrenal cortex. As adrenal function declines, the body may become unable to produce adequate amounts of important adrenal hormones, including cortisol and aldosterone.
The Kashi Addison’s Disease Genetic Test evaluates specific Human Leukocyte Antigen (HLA) variants associated with an increased genetic susceptibility to autoimmune Addison’s disease.
What Does the Test Evaluate?
Genetic susceptibility to autoimmune Addison’s disease has been associated with particular genes within the Major Histocompatibility Complex (MHC).
The Kashi test evaluates HLA markers associated with Addison’s disease, including:
HLA-DR3 HLA-DR4
Certain HLA patterns are found more frequently in individuals with autoimmune Addison’s disease and may provide additional information about inherited susceptibility.
Symptoms of Addison’s Disease
Symptoms can develop gradually and may include:
• Persistent fatigue and weakness • Low blood pressure • Lightheadedness, particularly when standing • Loss of appetite • Nausea or gastrointestinal symptoms • Salt cravings • Unexplained weight loss • Increased skin pigmentation
Genetic Susceptibility vs. Adrenal Function Testing
This test evaluates genetic susceptibility. It does not determine whether your adrenal glands are currently functioning normally and does not by itself diagnose Addison’s disease.
When Addison’s disease or adrenal insufficiency is suspected, additional testing may include morning cortisol, ACTH, electrolytes, renin, aldosterone, adrenal antibodies, and an ACTH stimulation test, depending on the clinical situation.
