Description

Ankylosing Spondylitis (AS) is a chronic autoimmune condition that primarily causes inflammation of the spine and sacroiliac joints. It can also affect peripheral joints and organs, including the eyes, skin, and gastrointestinal tract. Early diagnosis and monitoring are crucial to managing disease progression and improving quality of life.

This blood panel is designed to help identify key biomarkers associated with inflammation and genetic predisposition to AS. It supports both diagnosis and disease activity monitoring.

Included Biomarkers and Tests:

Complete Blood Count (CBC):

The CBC measures various components of the blood, including white blood cells (WBC), red blood cells (RBC), hemoglobin, hematocrit, and platelets.

  • Why it's important:
  • Detects anemia (common in chronic disease), elevated WBCs (indicative of inflammation or infection), and other hematologic changes associated with systemic inflammation.

C-Reactive Protein (CRP):

CRP is an acute-phase protein produced by the liver in response to systemic inflammation.

  • Why it's important:
  • CRP levels rise in response to inflammation and are often elevated in individuals with active AS. It is commonly used to monitor disease activity and treatment response.

HLA-B27 Genotyping:

This test detects the presence of the HLA-B27 antigen, a genetic marker strongly associated with AS and other spondyloarthropathies.

  • Why it's important:
  • While not diagnostic on its own, a positive HLA-B27 result increases the likelihood of AS, particularly when symptoms are present.

Test Preparation:

  • Fasting: Not required
  • Sample Type: Blood (venipuncture)

Who Should Consider This Panel?

This panel may be appropriate for individuals experiencing:

  • Chronic lower back pain and stiffness, especially in the morning or after rest
  • Joint pain in the hips, knees, or ankles
  • Fatigue, eye inflammation, or unexplained weight loss
  • A family history of ankylosing spondylitis or other autoimmune diseases

Clinical Use Cases:

  • Supporting diagnosis of ankylosing spondylitis
  • Evaluating systemic inflammation
  • Genetic risk assessment for HLA-B27-associated conditions
  • Monitoring disease activity and response to treatment