Description

The Celiac, IBS, and Crohn’s Assay (CICA) is a comprehensive test that evaluates both genetic and serological markers associated with celiac disease and Crohn’s disease. This dual approach provides a thorough assessment of an individual’s risk and current immune activity related to these complex autoimmune and inflammatory gastrointestinal conditions.

By analyzing multiple biomarkers, the CICA test aids in diagnosis, guides treatment decisions, and supports personalized patient care.

Biomarkers Tested

Genetic Markers:

  • ATG16L1: Linked to Crohn’s disease susceptibility by influencing immune regulation and intestinal cell maintenance.
  • HLA-DQ2 & HLA-DQ8: Key genetic variants strongly associated with celiac disease risk.
  • NOD2: Important in immune response to bacterial components; variants contribute to Crohn’s disease risk.

Serological Markers:

  • Anti-DGP IgA & IgG (Deamidated Gliadin Peptide antibodies): Indicators of celiac disease immune response.
  • Anti-tTG IgA & IgG (Tissue Transglutaminase antibodies): Primary markers used to diagnose celiac disease.
  • S. cerevisiae IgA & IgG (Anti-Saccharomyces cerevisiae antibodies): Commonly elevated in Crohn’s disease, aiding differentiation from other inflammatory bowel diseases.
  • Total IgA: Measures overall IgA levels to assess for selective IgA deficiency, which can affect test interpretation.

Why Choose the CICA Test?

  • Comprehensive Evaluation: Combines genetic predisposition with current immune activity for a holistic assessment.
  • Early Detection & Monitoring: Helps identify disease risk and active immune responses even before symptoms become severe.
  • Differential Diagnosis: Assists in distinguishing between celiac disease, Crohn’s disease, and irritable bowel syndrome (IBS).
  • Personalized Care: Supports tailored treatment and dietary recommendations based on your unique biomarker profile.

Collection Information

  • Sample Type: Blood draw required
  • Fasting: Fasting is required for this test to ensure accurate serological results.

Who Should Consider the CICA Test?

  • Individuals with gastrointestinal symptoms suggestive of celiac disease, Crohn’s disease, or IBS
  • Patients with a family history of autoimmune digestive disorders
  • Those needing a clearer diagnosis when symptoms overlap between celiac disease and Crohn’s disease
  • Healthcare providers seeking detailed genetic and serological information to guide management