Description

The CICA Genetics test is a specialized genetic screening tool designed to evaluate key genetic markers linked to celiac disease and Crohn’s disease — two complex autoimmune and inflammatory disorders affecting the digestive system.

By analyzing variants in critical genes, this test helps assess an individual’s inherited risk of developing these conditions, enabling early diagnosis, personalized treatment plans, and proactive management.

What Are Celiac Disease and Crohn’s Disease?

  • Celiac Disease is an autoimmune disorder triggered by gluten consumption, causing inflammation and damage to the small intestine. Symptoms may include digestive discomfort, nutrient malabsorption, fatigue, and skin issues. Genetic predisposition plays a significant role in disease development.
  • Crohn’s Disease is a chronic inflammatory bowel disease (IBD) characterized by inflammation anywhere along the gastrointestinal tract. It can cause abdominal pain, diarrhea, weight loss, and systemic complications. Genetics, immune function, and environmental factors contribute to disease risk.

Biomarkers Tested

  • ATG16L1: A gene involved in the regulation of autophagy (cellular cleanup), variants in ATG16L1 are associated with increased susceptibility to Crohn’s disease by impacting immune response and intestinal health.
  • HLA-DQ2 and HLA-DQ8: These human leukocyte antigen (HLA) gene variants are strongly linked to celiac disease risk. Presence of either variant significantly increases the likelihood of gluten sensitivity and disease development.
  • NOD2: Variants in this gene affect the body’s ability to recognize bacterial components and regulate inflammation, contributing to Crohn’s disease susceptibility.

Why Choose the CICA Genetics Test?

  • Early Risk Assessment: Understand your genetic predisposition before symptoms arise or in early stages of disease.
  • Personalized Healthcare: Inform targeted screening, dietary guidance, and treatment plans based on your genetic profile.
  • Family Planning: Provides valuable information for individuals with a family history of celiac or Crohn’s disease.
  • Non-Invasive: Requires only a simple blood draw; fasting is not required.

Who Should Consider This Test?

  • Individuals with a family history of celiac disease or Crohn’s disease
  • Patients with unexplained gastrointestinal symptoms
  • Those seeking to understand their genetic risk for autoimmune digestive disorders
  • Healthcare providers looking to supplement clinical evaluation with genetic data