Description
The DUTCH Plus® is one of the most comprehensive hormone assessments available from Precision Analytical. It combines the extensive hormone and metabolite testing of the DUTCH Complete® with multiple saliva samples to evaluate the Cortisol Awakening Response (CAR).
This provides a detailed look at sex hormones, adrenal function, cortisol patterns, hormone metabolism, and organic acids related to nutritional and metabolic health.
What Does DUTCH Plus Measure?
Estrogens & Estrogen Metabolism
Evaluates estrogens and their metabolites, providing insight into how the body produces and metabolizes estrogen.
Progesterone
Measures progesterone metabolites that can help assess progesterone production.
Androgens
Evaluates testosterone, DHEA-S and androgen metabolites, including pathways involving DHT.
Cortisol & Cortisone
Measures free and metabolized cortisol and cortisone to provide a more complete picture of adrenal hormone production and cortisol metabolism.
Cortisol Awakening Response (CAR)
The DUTCH Plus adds saliva testing around the time of awakening to evaluate the body's natural rise in cortisol after waking.
The CAR can provide additional information about the hypothalamic-pituitary-adrenal (HPA) axis and stress response.
Daily Cortisol Rhythm
Multiple samples throughout the day show how cortisol changes from morning through bedtime rather than providing only a single measurement.
Organic Acids
DUTCH testing also includes select organic-acid markers related to areas such as:
- Vitamin B12
- Vitamin B6
- Glutathione
- Biotin
- Dopamine metabolism
- Norepinephrine/epinephrine metabolism
- Melatonin
- Oxidative stress
Who May Consider DUTCH Plus?
DUTCH Plus may be useful for individuals interested in evaluating:
- Fatigue or low energy
- Stress and adrenal function
- Sleep problems
- Menopause or perimenopause
- PMS or irregular menstrual cycles
- Hormonal symptoms
- Low libido
- Mood changes
- Hormone replacement therapy monitoring
- Testosterone therapy
- Estrogen metabolism
- Cortisol abnormalities
- Overall hormone optimization
Convenient At-Home Collection
DUTCH Plus uses dried urine and saliva samples, allowing the entire collection to be completed at home.
No traditional blood draw is required.
Because hormones and cortisol change throughout the day, samples are collected at specific times according to the instructions provided with the kit.
We Can Ship the DUTCH Plus Kit Directly to You

