Description

Comprehensive Blood Panel to Monitor Iron Overload

For individuals diagnosed with hereditary hemochromatosis or those at risk, ongoing monitoring of iron status is essential to manage iron overload and prevent organ damage. This panel measures key iron-related biomarkers to evaluate total body iron stores and iron transport efficiency.

Biomarkers Included

  • Serum Ferritin
  • Ferritin is a protein that stores iron inside cells. Measuring serum ferritin reflects the amount of stored iron in the body. Elevated ferritin levels often indicate iron overload but can also rise with inflammation or liver disease.

  • Total Iron Binding Capacity (TIBC)
  • TIBC estimates the maximum amount of iron that transferrin (the main iron transport protein) can carry. High TIBC often suggests iron deficiency, while low values may be seen in iron overload or chronic illness.
  • Transferrin Saturation (%)
  • Calculated by dividing serum iron by TIBC, transferrin saturation shows the percentage of transferrin binding sites occupied by iron. Saturation above 45% is suggestive of iron overload, commonly seen in hemochromatosis.

Why Monitor These Markers?

  • To track iron accumulation and guide treatment decisions such as phlebotomy (regular blood removal).
  • To differentiate iron overload from other causes of elevated ferritin, such as inflammation or liver disease.
  • To assess response to treatment and prevent complications related to excess iron, including liver cirrhosis, diabetes, and heart disease.

Sample Collection & Turnaround Time

  • Blood draw required (fasting not usually necessary).
  • Results typically available within 1–3 business days.

Who Should Use This Panel?

  • Patients diagnosed with hereditary hemochromatosis.
  • Individuals with elevated serum ferritin or transferrin saturation found on screening.
  • Patients undergoing treatment for iron overload needing regular monitoring.
  • Anyone with symptoms or family history suggestive of iron metabolism disorders.