Description

HuMap™ – Hormone and Urinary Metabolites Assessment Profile

Shipped Nationwide | At-Home Collection | Urine-Based Test

Comprehensive Urinary Hormone & Metabolite Analysis

The HuMap™ Profile is a cutting-edge urine-based hormone test that provides a full-spectrum view of steroid hormone levels, metabolites, and enzymatic activity related to hormone metabolism. It evaluates estrogens, androgens, progesterone, DHEA, and cortisol rhythms, as well as metabolic ratios that help reveal how efficiently your body processes and detoxifies hormones.

This test is ideal for uncovering hormone imbalances, identifying detoxification bottlenecks, and supporting personalized hormone-related treatment strategies.

What the HuMap™ Tests

The HuMap™ provides insights into:

Hormone Pathways & Metabolism

Understand how your body is producing and breaking down hormones.

  • Estrogens (E1, E2, E3)
  • Progesterone & Pregnanediols (α, β)
  • Androgens (Testosterone, DHEA, Androstenedione)
  • Estrogen Detoxification Pathways:
  • 2-OH, 4-OH, and 16-OH estrogen metabolites
  • Methylation efficiency markers (e.g., 2-MeO-E1, 4-MeO-E2)
  • Ratios like 2-OH/16-OH-E1 and 4-OH-E1/2-OH-E1

Adrenal Function & Diurnal Cortisol Rhythm

Assess stress response and HPA-axis function across four time points:

  • Cortisol: Morning, Afternoon, Evening, Night
  • Cortisone: Matching four time points
  • Cortisol/Cortisone Ratio
  • THE, THF, 5α-THF, 5β-THF: Cortisol metabolism and clearance markers

Neurosteroids & Mood-Modulating Metabolites

These markers can influence mental health, mood, and neurological function:

  • Allopregnanolone
  • 5α-Androstanediol / 5β-Androstanediol
  • Pregnanetriol

DNA Oxidative Stress Marker

  • 8-OHdG (8-hydroxy-2'-deoxyguanosine): A biomarker for oxidative DNA damage and cellular stress, often elevated in chronic stress, toxin exposure, or inflammation.

Full Biomarker Panel Includes:

Androgens & Metabolites

  • Testosterone
  • Epi-Testosterone
  • Androstenedione
  • Androsterone
  • Etiocholanolone
  • 5α-Androstanediol
  • 5β-Androstanediol
  • Androsterone/Etiocholanolone Ratio

Estrogens & Metabolites

  • Estrone (E1)
  • Estradiol (E2)
  • Estriol (E3)
  • 2-OH-E1, 4-OH-E1, 16-OH-E1
  • 2-MeO-E1, 4-MeO-E1
  • 2-MeO-E2, 4-MeO-E2
  • 2-OH-E1/16-OH-E1 Ratio
  • 4-OH-E1/2-OH-E1 Ratio
  • Methylation ratios (2-MeO/2-OH, 4-MeO/4-OH)

Progesterone & Metabolites

  • Progesterone
  • 17-Hydroxyprogesterone
  • 21-Hydroxyprogesterone
  • α-Pregnanediol
  • β-Pregnanediol
  • Pregnanetriol

Adrenal Hormones & Metabolism

  • DHEA
  • DHEA-S
  • DHEA + DHEA-S
  • Cortisol (4-point: waking, morning, evening, night)
  • Cortisone (same four time points)
  • Cortisol/Cortisone Ratio
  • THE (Tetrahydrocortisone)
  • THF (5α, 5β variants)
  • 5a-THF/5b-THF Ratio
  • 5a-THF+5b-THF/THE Ratio
  • 11-Deoxycortisol
  • Corticosterone
  • Tetrahydrodehydrocorticosterone
  • 5a-Tetrahydrocorticosterone
  • 5b-Tetrahydrocorticosterone

Oxidative Stress

  • 8-OHdG

Creatinine – Used for normalizing all urinary results

What You Get With the Report

✅ Detailed analysis of over 60 hormones and metabolites

✅ Visualization of hormone production and detox pathways

✅ Cortisol rhythm graph across the day (4-point)

✅ Estrogen metabolism maps showing methylation efficiency

✅ Hormone ratios and enzyme activity insights (5α/5β pathways, COMT methylation, etc.)

✅ Clear clinical interpretation with personalized commentary

✅ Treatment suggestions for hormone balance, stress support, and detox enhancement (when applicable)

Who Should Consider the HuMap™ Test?

This test is ideal for both men and women who are experiencing:

  • Hormonal symptoms like PMS, irregular cycles, or perimenopause
  • Hot flashes, night sweats, or low libido
  • Suspected estrogen dominance or poor estrogen detox
  • Mood swings, anxiety, or depression
  • Chronic fatigue or sleep disturbances
  • Adrenal fatigue or burnout
  • Symptoms of PCOS or testosterone imbalances
  • Men with concerns about low testosterone, DHT, or estrogen conversion
  • Anyone with a history of hormone-related cancers (breast, prostate, etc.) seeking insight into estrogen metabolism
  • Individuals exposed to environmental toxins or endocrine disruptors

Shipping & Processing

  • Shipping Time: 3–5 Business Days (Nationwide)
  • Average Sample Processing Time: 8 Business Days
  • Specimen Type: Four-point urine collection (waking, morning, afternoon, night)