Description

Comprehensive brain chemistry & stress hormone testing – including diurnal melatonin and cortisol patterns

The Neurotransmitters + UDH II profile is a complete urine-based assessment of neurotransmitter balance and diurnal hormone rhythms, including cortisol, cortisone, and melatonin throughout the day. This panel offers an in-depth view of how brain chemistry and stress/adrenal function interact to affect mood, sleep, focus, and energy.

At-home urine collection kit shipped nationwide

What This Test Measures

This panel evaluates over 35 biomarkers to help identify:

  • Mood and anxiety imbalances (e.g., low serotonin, high glutamate)
  • Sleep issues (e.g., melatonin rhythm disruption)
  • Stress dysregulation (e.g., cortisol/cortisone imbalance)
  • ADHD or attention issues (e.g., dopamine, PEA)
  • Chronic fatigue or low motivation
  • Neuroinflammation or excitotoxicity

Neurotransmitters & Related Compounds

These markers give insight into how well your brain communicates through chemical messengers. Imbalances are often linked to depression, anxiety, ADHD, OCD, and insomnia.

  • Dopamine – Motivation, focus, pleasure
  • DOPAC – Dopamine metabolite; reflects dopamine turnover
  • Norepinephrine – Alertness, stress response, heart rate
  • Epinephrine (Adrenaline) – Fight-or-flight hormone; energy and panic response
  • NE/Epi Ratio – Balances norepinephrine and epinephrine activity
  • Normetanephrine – Norepinephrine metabolite; indicates stress response
  • VMA (Vanillylmandelic Acid) – End product of catecholamine metabolism
  • HVA (Homovanillic Acid) – Dopamine metabolite; linked to mood and reward
  • PEA (Phenylethylamine) – Mood, focus, emotional regulation
  • GABA (Gamma-Aminobutyric Acid) – Calming neurotransmitter; reduces over-excitation
  • Glutamate – Major excitatory neurotransmitter; learning and memory
  • Glutamine – Precursor to both GABA and glutamate
  • Glycine – Inhibitory neurotransmitter; supports sleep and muscle relaxation
  • Serotonin – Mood regulation, sleep, appetite, and pain
  • 5-HIAA – Primary metabolite of serotonin
  • Histamine – Immune response, emotion, and wakefulness
  • N-Methylhistamine – Histamine metabolite; measures histamine activity
  • Histidine – Precursor to histamine
  • Taurine – Calming amino acid; supports bile flow and neurological health
  • Tryptophan – Precursor to serotonin and melatonin
  • Tyrosine – Precursor to dopamine, norepinephrine, and epinephrine
  • Tyramine – Trace amine that influences neurotransmitter release
  • Kynurenine – Tryptophan metabolite; reflects inflammation and neurodegeneration risk
  • 3-Hydroxykynurenine – Intermediate metabolite in tryptophan breakdown; neurotoxic at high levels
  • Kynurenic Acid – Neuroprotective compound that balances excitatory signals
  • Xanthurenic Acid – Reflects altered tryptophan metabolism; may be linked to mood issues

Diurnal Cortisol & Cortisone (4 Points)

This portion of the test shows how your stress hormone levels fluctuate throughout the day — critical for energy, immunity, metabolism, and adrenal function.

  • Cortisol – Morning, Noon, Evening, Night – Tracks energy and stress hormone output across the day
  • Cortisone – Morning, Noon, Evening, Night – Inactive form of cortisol; gives insight into conversion and clearance rates

Diurnal Melatonin (4 Points)

Melatonin regulates sleep-wake cycles. Testing it across four timepoints can reveal disruptions in circadian rhythm, insomnia, or excessive daytime fatigue.

  • Melatonin – Morning, Noon, Evening, Night – Helps assess sleep disorders and light/dark cycle misalignment

Additional Marker

  • Creatinine – Used to standardize results and validate urine concentration

Who Should Consider This Test?

This panel is ideal for individuals experiencing:

  • Anxiety, depression, or irritability
  • Sleep difficulties or insomnia
  • Chronic stress or burnout
  • Difficulty focusing (ADHD, brain fog)
  • PMS, PMDD, or hormone-related mood swings
  • Fatigue that doesn’t improve with rest
  • Suspicion of neuroinflammation or neurotransmitter imbalances

Test Overview

  • Specimen Type: Urine (4 time points: Morning, Noon, Evening, Night)
  • Collection Method: At-home collection kit
  • Shipping: Nationwide (USA)