Description

Advanced Functional Urine Analysis for Metabolic Health

The OMX™ Organic Metabolomics – Urine Test offers an extensive view into the biochemical landscape of the body using metabolomic profiling. This test assesses a wide spectrum of organic acids, amino acids, neurotransmitter metabolites, oxidative stress markers, and gut-derived compounds—revealing a patient’s Metabolic Signature™ and uncovering root-cause imbalances.

Sample Type:

Urine (first morning void recommended)

Turnaround Time:

10–14 business days

Detailed Biomarker Categories & Clinical Insights

1. Energy Production & Mitochondrial Function (Krebs Cycle Metabolites)

These markers assess mitochondrial efficiency and cellular energy production.

  • Citric Acid, Succinic Acid, Fumaric Acid, Malic Acid, Isocitric Acid, Cis-Aconitic Acid, a-Ketoglutaric Acid
  • Evaluate the integrity of the citric acid cycle (TCA/Krebs cycle)
  • Abnormalities may reflect fatigue, poor mitochondrial output, or nutrient cofactor deficiencies (e.g., B-vitamins, magnesium)
  • Lactic Acid, Pyruvic Acid
  • Indicators of glycolytic pathway overload or mitochondrial dysfunction
  • Elevated in hypoxia, oxidative stress, or impaired glucose metabolism

2. Amino Acids & Nitrogen Metabolism

Assess protein digestion, nutrient status, detoxification, and neurotransmitter precursors.

  • Essential/Branched Chain Amino Acids: Valine, Leucine, Isoleucine
  • Crucial for muscle metabolism, neurotransmitter synthesis, and recovery
  • Depletion may indicate catabolism or malabsorption
  • Other Key Amino Acids: Glycine, Serine, Methionine, Threonine, Alanine, Proline, Lysine
  • Important in methylation, neurotransmission, collagen formation, and antioxidant pathways
  • Functional Ratios:
  • Glutamine/Glutamate Ratio – balance between excitatory and calming neurotransmission
  • Kynurenine/Tryptophan Ratio – evaluates inflammation-driven tryptophan metabolism
  • Urea Cycle Metabolites: Citrulline, Arginine, Ornithine, Aspartic Acid, Argininosuccinic Acid
  • Reflect nitrogen detoxification capacity and potential ammonia overload

3. Neurotransmitter Metabolism

Analyzes dopamine, serotonin, and GABA breakdown products.

  • HVA (Homovanillic Acid) – Dopamine metabolite
  • VMA (Vanillylmandelic Acid) – Norepinephrine/epinephrine breakdown
  • 5-HIAA (5-Hydroxyindoleacetic Acid) – Serotonin metabolite
  • GABA – Primary inhibitory neurotransmitter
  • Kynurenine Pathway Metabolites: Kynurenine, Kynurenic Acid, Quinolinic Acid, Xanthurenic Acid
  • Reflects tryptophan metabolism and immune system activation

4. Detoxification & Oxidative Stress Markers

  • Glucaric Acid, Hippuric Acid, Mandelic Acid, Benzoic Acid – Phase I and II liver detox intermediates
  • 8-OHdG (8-Hydroxy-2'-deoxyguanosine) – Oxidative DNA damage marker
  • Methylsuccinic Acid, Ethylmalonic Acid – Impaired fatty acid metabolism
  • Oxalic Acid, Picolinic Acid, Pyridoxic Acid – Linked to B-vitamin status and detox cofactor usage

5. Gut Microbial Metabolites

Reflect gut dysbiosis and microbial overgrowth.

  • Arabinitol – Marker of yeast/fungal overgrowth (e.g., Candida)
  • Tartaric Acid, Citramalic Acid – Microbial fermentation byproducts
  • Phenylacetic Acid, 4-Hydroxybenzoic Acid, 3-Indoleacetic Acid – Produced by gut bacteria or from amino acid degradation
  • Equol – A metabolite of soy isoflavones by certain gut microbes

6. Fatty Acid & Carnitine Metabolism

  • Adipic Acid, Suberic Acid, Sebacic Acid, Glutaric Acid
  • Indicators of medium-chain and long-chain fatty acid oxidation
  • Elevations may be associated with mitochondrial dysfunction or carnitine deficiency

7. Nutrient Cofactors & Vitamin Metabolism

  • Formiminoglutamic Acid (FIGLU) – Marker of folate (B9) deficiency
  • Pyridoxic Acid – Reflects vitamin B6 metabolism
  • Orotic Acid – Indicates urea cycle dysfunction and possible ammonia accumulation
  • MMA (Methylmalonic Acid) – Sensitive indicator of vitamin B12 deficiency

8. Additional Functional Markers

  • Creatinine – Used for normalization and kidney function baseline
  • Microalbumin – Early indicator of renal damage or vascular inflammation
  • Phosphate, Phosphoethanolamine – Indicators of cellular membrane turnover
  • Taurine, Cystine, Cystathionine, Sulfocysteine – Related to sulfur amino acid and glutathione pathways

Why Use the OMX™ Urine Panel?

  • Uncovers metabolic bottlenecks not visible in standard labs
  • Identifies functional nutrient deficiencies and cofactor imbalances
  • Supports precision treatment plans in functional and integrative medicine
  • Provides a comprehensive metabolic roadmap for complex chronic cases