Description

Comprehensive Gut Health and Immune Reactivity Evaluation

The P88 Dietary Antigen Test + Advanced Intestinal Barrier Assessment (AIBA) is a dual-panel diagnostic tool designed to provide a complete picture of gut health, intestinal permeability, and food-related immune reactivity. This test combines the strengths of two advanced evaluations into one:

  • AIBA (Advanced Intestinal Barrier Assessment): Measures the integrity of the gut lining through detection of antibodies to zonulin and lipopolysaccharides (LPS)—key markers of intestinal permeability and endotoxin exposure.
  • P88 Dietary Antigen Test: Screens for immune responses (IgA, IgG, IgE, IgM, and complement activation) to 88 common foods and microbial antigens, including yeast, molds, and bacteria.

Together, these assessments provide deep insights into gut-immune interactions, helping clinicians identify underlying triggers of:

  • Chronic inflammation
  • Autoimmune disease
  • Digestive dysfunction
  • Skin conditions
  • Mood disorders
  • Fatigue and brain fog

Key Biomarkers

Intestinal Barrier Integrity (AIBA):

  • Zonulin – Regulator of tight junctions; elevated in leaky gut
  • Anti-LPS IgA / IgG / IgM – Antibodies to endotoxins from gram-negative bacteria, indicating increased gut permeability and immune activation
  • DAO (Diamine Oxidase) – Enzyme that breaks down histamine; low levels may indicate histamine intolerance

Food & Microbial Antigens (P88 Dietary Antigen Test):

Includes testing for antibody reactivity (IgG, IgA, IgM, and complement) to 88 common dietary and environmental antigens:

Foods:

  • Dairy: Cow Milk, Goat Milk, Casein, Egg White, Egg Yolk, Egg Albumin
  • Grains: Wheat, Barley, Rye, Oats, Rice, Corn, Gluten
  • Legumes: Soybean, Peanuts, Green Pea, Lima Bean, Navy Bean, Kidney Bean
  • Nuts & Seeds: Almond, Cashew, Flaxseed, Sesame, Pecan, English Walnut
  • Fruits: Apple, Banana, Blueberry, Cantaloupe, Cherry, Grape, Grapefruit, Lemon, Orange, Peach, Pear, Pineapple, Plum, Strawberry, Watermelon
  • Vegetables: Broccoli, Cabbage, Cauliflower, Carrot, Celery, Cucumber, Garlic, Green Pepper, Lettuce, Mushroom, Onion, Spinach, Sweet Potato, Tomato, Yellow Squash, Asparagus
  • Proteins: Beef, Chicken, Pork, Turkey, Codfish, Halibut, Tuna, Flounder, Salmon, Scallops, Shrimp, Lobster, Clam, Crab
  • Other Foods: Coffee, Tea, Cacao, Cinnamon, Vanilla, Mustard, Hops, Green Olive, Cottonseed

Microbial Antigens:

  • Candida spp.
  • Aspergillus spp.
  • Brewer's Yeast

Why This Test Is Important:

  • Identifies hidden food sensitivities and delayed immune reactions that may not show up on traditional allergy panels.
  • Assesses gut permeability, a contributing factor to:
  • Autoimmune diseases
  • Chronic fatigue
  • Cognitive issues
  • Skin problems (eczema, psoriasis)
  • Detects immune system activation to dietary and environmental triggers.
  • Supports personalized nutrition plans and targeted gut repair protocols.

Ideal For Patients With:

  • Leaky Gut Syndrome
  • Autoimmune Conditions
  • IBS/IBD
  • Chronic Inflammation
  • Fatigue and Brain Fog
  • Food Intolerances
  • Skin or Mood Disorders
  • Post-COVID or post-infection dysbiosis

Sample Type:

  • Serum (Blood Test)
  • Fasting is not required.