Description

Get the full picture of your hormone cycle, stress response, and sleep-wake rhythm.

The Rhythm Plus™ + CAR test is the most advanced salivary hormone panel available for premenopausal and perimenopausal women who are not currently using hormone therapy. This test tracks hormone levels over a full 28-day menstrual cycle and includes three powerful assessments in one:

  • Adrenocortex Stress Profile (daily cortisol & DHEA)
  • Cortisol Awakening Response (CAR)
  • Comprehensive Melatonin Profile

Together, these panels offer a complete, non-invasive view of your sex hormones, stress system, and circadian regulation—giving you and your provider actionable insight into what may be causing symptoms like PMS, fatigue, irregular cycles, mood swings, or sleep issues.

Why Rhythm Plus™ + CAR Is Different

Many hormone imbalances are missed by one-time blood tests. Hormones fluctuate hour by hour and day by day—especially during the menstrual cycle. This test captures those changes in real time across an entire month.

It also includes the Cortisol Awakening Response, which evaluates your body’s immediate stress readiness within the first hour of waking—a powerful indicator of adrenal resilience, burnout, or chronic stress.

Ideal For Women With:

  • Irregular or painful periods
  • PMS or PMDD symptoms
  • Perimenopausal changes (even with regular cycles)
  • Fatigue or low energy
  • Anxiety or emotional ups and downs
  • Low libido
  • Sleep disturbances or feeling “wired but tired”
  • Chronic stress or suspected adrenal burnout
  • Unexplained infertility or ovulatory issues

What This Test Measures

Collected through saliva samples at scheduled intervals over 28 days, this test tracks patterns in the following biomarkers:

Cortisol

Measured multiple times daily, including the Cortisol Awakening Response (CAR). Evaluates the strength and shape of your daily cortisol rhythm.

DHEA

An adrenal hormone that supports estrogen and testosterone production. Helps assess stress recovery and aging.

Estradiol (E2)

Tracks your body’s estrogen production over the month. Key for ovulation, energy, skin, and mood.

Progesterone

Measured in the second half of the cycle to assess ovulation and balance with estrogen. Low levels may be linked to anxiety, PMS, and short cycles.

Testosterone

Essential for libido, energy, motivation, and muscle tone. Imbalances are common in PCOS and hormonal fatigue.

Melatonin

Measured overnight to assess sleep quality and circadian rhythm health. Low melatonin is linked to insomnia, stress, and hormonal aging.

Fasting: Not required

Test Duration: 28 days

Specimen Type: Saliva

Includes: Cortisol Awakening Response (CAR), Adrenal Profile, Melatonin Profile

Availability: Nationwide

The Rhythm Plus™ + CAR is your best choice if you want to understand your hormone cycle in detail and identify how stress and circadian function may be impacting your reproductive and emotional health.