Description

Saliva Hormone Opendx Supreme

At-home saliva collection | Nationwide shipping

Overview

The Saliva Hormone Opendx Supreme test provides a precise, non-invasive assessment of 11 key hormones—measured across multiple time points—using liquid chromatography-tandem mass spectrometry (LC/MS-MS). This highly accurate method detects even low concentrations of hormones, making it superior to immunoassay testing for both men and women.

It includes a four-point cortisol profile to evaluate adrenal function, in addition to essential sex hormones and melatonin, offering deep insight into the balance between stress, sleep, metabolism, and reproductive health.

Shipping & Turnaround

  • Sample Type: Saliva (collected with timed tubes at home)
  • Shipping: 1–6 business days (shipped nationwide)
  • Sample Processing Time: 3 business days on average

Hormones Measured & Clinical Relevance

Sex & Reproductive Hormones

  • Testosterone
  • Primary male sex hormone (also important in women). Influences libido, energy, muscle mass, and mood. Low levels can cause fatigue, depression, and decreased vitality.
  • DHT (Dihydrotestosterone)
  • A potent derivative of testosterone. Elevated levels are linked to acne, hair loss (androgenic alopecia), and prostate enlargement.
  • Androstenedione
  • Precursor to both estrogens and androgens. Helps detect adrenal or gonadal dysfunction. Elevated in PCOS or adrenal hyperplasia.
  • Progesterone
  • Produced after ovulation. Supports menstrual cycle balance, fertility, mood, and sleep. Low levels can lead to estrogen dominance, PMS, or miscarriage risk.
  • 17-Hydroxyprogesterone
  • A key adrenal steroid precursor. Elevated in congenital adrenal hyperplasia (CAH) or stress; useful in differentiating adrenal from ovarian hormone issues.
  • Estrone (E1)
  • Weak estrogen; becomes the dominant form after menopause. Excess may indicate estrogen dominance or poor detoxification.
  • Estradiol (E2)
  • The most active estrogen during reproductive years. Essential for menstrual health, bone density, mood stability, and skin elasticity.
  • Estriol (E3)
  • Protective and mild estrogen. Elevated in pregnancy; low levels may indicate estrogen deficiency.

Adrenal Function – Diurnal Cortisol (4 points)

Assesses cortisol at four strategic times to evaluate adrenal gland output and circadian rhythm.

Ideal for identifying adrenal fatigue, burnout, or chronic stress responses.

  • Cortisol – Morning (30 minutes after waking)
  • Reflects the Cortisol Awakening Response (CAR). Should be the highest point of the day. Blunted response suggests adrenal fatigue or HPA-axis dysfunction.
  • Cortisol – Noon
  • Measures midday adrenal activity. Helps determine how well your energy and stress hormones are maintained through the day.
  • Cortisol – Evening
  • Should begin to decline. Elevated results suggest inability to wind down, commonly seen with chronic stress, anxiety, or insomnia.
  • Cortisol – Night
  • Final cortisol level before sleep. Elevated levels are associated with poor sleep quality, nighttime waking, and weight gain.

Melatonin (2 points)

  • Melatonin – Morning
  • Should be low in the morning. Elevated morning melatonin may signal circadian rhythm disruption or pineal gland dysfunction.
  • Melatonin – Night
  • Reflects nighttime production. Low levels are linked to insomnia, difficulty falling asleep, and mood disorders.

Collection Timing & Preparation

For Men & Non-Menstruating Women:

Collect samples any day.

For Menstruating Women:

  • Regular cycles: Collect on Day 19–21 of the cycle (Day 1 = first day of period)
  • Irregular cycles: Collect when not bleeding, closest to Day 19–21

Hormone Therapy Timing:

  • Daily patch, gel, cream, pill, spray: Collect 12–24 hours after last dose
  • Sublingual or troche forms: Wait 36 hours after last dose
  • Weekly patch or injections: Follow provider guidance

Avoid for 2 Hours Before Sample Collection:

  • Eating or drinking
  • Brushing teeth or using mouthwash

Avoid on Collection Day:

  • Caffeine
  • Alcohol

Who Should Take This Test?

This test is ideal for individuals who:

  • Suspect hormone imbalance, including low energy, mood swings, PMS, or weight gain
  • Experience fatigue, burnout, or disrupted sleep
  • Are undergoing or considering bioidentical hormone therapy (BHRT)
  • Have symptoms of adrenal insufficiency or chronic stress
  • Want to assess sleep disorders, perimenopause, or menopause status

What You’ll Receive

  • Pre-labeled saliva collection tubes (for 4x cortisol + 2x melatonin + hormone panel)
  • Complete, physician-reviewed lab report
  • Hormone patterns with clinical interpretation
  • Color-coded reference ranges for easy visualization