Description

Serum protein electrophoresis (SPEP) is a blood test that measures the levels of specific proteins in your blood. It's used to help identify diseases like multiple myeloma, kidney disease, and liver disease. 

How it works 

  • An electrical field separates the proteins in your blood into groups based on their size, shape, and charge
  • Each group moves at a different rate through the field, creating a pattern
  • The pattern helps doctors identify diseases

What it can help identify

  • Multiple myeloma
  • A blood cancer that can be detected by measuring the level of paraprotein in your blood 
  • Other serum protein disorders
  • Such as monoclonal gammopathy, which can be indicated by a spike-like peak in the gamma-globulin zone 
  • Other diseases
  • Such as kidney disease, liver disease, anemia, diabetes, thyroid problems, malnutrition, and autoimmune diseases 

Fasting not required.