Description
Pinpointing the Root Cause of Persistent Tiredness
The Unexplained Fatigue Panel is a targeted diagnostic tool designed to uncover underlying medical causes of chronic fatigue. By evaluating autoimmune activity, inflammatory markers, and immune system dysfunction, this panel helps identify conditions such as autoimmune thyroid disease, rheumatoid arthritis, celiac disease, and systemic lupus erythematosus (SLE)—all of which may contribute to prolonged or unexplained fatigue.
What This Test Evaluates
This panel helps assess for:
- Autoimmune disorders
- Chronic inflammatory responses
- Hidden food-related immune triggers (e.g., gluten sensitivity)
- Rheumatologic and connective tissue conditions
Biomarkers Included
Autoimmune Activity
- ANA (Antinuclear Antibody) – Screening for autoimmune disorders like lupus
- Anti-dsDNA – Specific marker for SLE (systemic lupus erythematosus)
- RF IgA / RF IgM – Rheumatoid factor, markers for rheumatoid arthritis
- Anti-CCP IgG – Highly specific for rheumatoid arthritis
Celiac & Gluten-Related Autoimmunity
- Anti-DGP IgA / IgG – Antibodies to deamidated gliadin peptides (gluten sensitivity)
- Anti-tTG IgA / IgG – Antibodies to tissue transglutaminase, a key celiac disease marker
Who Should Consider This Panel?
This test is recommended for individuals experiencing:
- Persistent, unexplained fatigue lasting several weeks or more
- Joint pain, muscle aches, or brain fog
- Digestive issues combined with fatigue (potential gluten sensitivity)
- A personal or family history of autoimmune disease
- Negative results from routine lab work, yet ongoing symptoms
Test Details
- Sample type: Blood
- Fasting: Not required
- Turnaround time: Typically 5–7 business days
Tired of Not Knowing Why You're Tired?
The Unexplained Fatigue Panel delivers critical insights that can lead to early diagnosis, targeted treatments, and lasting relief. It’s a smart first step toward uncovering the hidden triggers of chronic exhaustion—so you can start feeling like yourself again.

