Description
The Zonulin Stool Test measures levels of zonulin, a protein that regulates the tight junctions between cells of the intestinal lining. Elevated levels of zonulin in stool may be a marker of increased intestinal permeability, commonly referred to as leaky gut.
What Is Leaky Gut?
Leaky gut occurs when the tight junctions in the gut lining become compromised, allowing partially digested food particles, toxins, and bacteria to pass through the intestinal wall and enter the bloodstream. This may trigger immune responses and inflammation, potentially contributing to a range of health issues such as:
- Food sensitivities
- Bloating and digestive discomfort
- Chronic fatigue
- Skin issues (e.g., eczema, acne)
- Autoimmune conditions
- Mood disturbances (e.g., anxiety, brain fog)
Clinical Significance:
The zonulin protein is the only known physiological regulator of intestinal permeability. Measuring zonulin levels in stool offers a non-invasive method to assess the health of the gut barrier and identify potential dysfunction.
Test Purpose:
This test helps detect increased intestinal permeability, supporting early identification and management of leaky gut-related conditions.
Sample Type:
Stool only
Patient Preparation:
No fasting required. Avoid antibiotics, probiotics, and NSAIDs for 3–5 days prior to collection unless directed otherwise by your healthcare provider.
Turnaround Time:
Results typically available within 5–7 business days of sample receipt.
Who Should Consider This Test?
Recommended for individuals experiencing persistent gastrointestinal symptoms, unexplained inflammation, autoimmune conditions, or other chronic health concerns potentially linked to compromised gut integrity.
