Autoimmune conditions affect millions of people and are often difficult to diagnose. Symptoms such as chronic fatigue, joint pain, muscle weakness, brain fog, rashes, or unexplained inflammation may persist for years before clear answers are found.

One reason autoimmune diseases are so challenging is that symptoms often overlap with other conditions, and basic lab tests may not reveal the full picture. The Autoimmune Antibody Profile Blood Test from Labs By Request is designed to help uncover underlying immune system activity and provide valuable diagnostic insight.

What Is the Autoimmune Antibody Profile?

The Autoimmune Antibody Profile is a comprehensive blood test that screens for a wide range of autoantibodies—proteins produced by the immune system that mistakenly target the body’s own tissues.

While a basic ANA (antinuclear antibody) test may indicate that autoimmune activity is present, it does not identify which autoimmune condition may be developing. This expanded profile goes further by testing for multiple specific antibodies associated with well-known autoimmune diseases.

This deeper level of testing can help guide more accurate diagnoses and support more targeted treatment decisions.

What Does the Test Measure?

The Autoimmune Antibody Profile evaluates numerous clinically relevant markers, including:

  • Rheumatoid Factor (RF) – commonly associated with rheumatoid arthritis

  • CCP IgG (Cyclic Citrullinated Peptide) – highly specific for rheumatoid arthritis

  • Anti-dsDNA and Smith (Sm) Antibodies – strongly associated with systemic lupus erythematosus

  • SS-A (Ro) and SS-B (La) Antibodies – linked to Sjögren’s syndrome and lupus

  • Thyroid Peroxidase (TPO) Antibody – a key marker of autoimmune thyroid disease, including Hashimoto’s thyroiditis

  • Scl-70 and Centromere B Antibodies – associated with scleroderma

Each antibody provides clues about immune system behavior and possible autoimmune patterns.

Why This Testing Is Important

Autoimmune diseases can be progressive and may cause irreversible tissue damage if left unrecognized. Identifying immune dysfunction earlier allows patients and clinicians to:

  • Clarify unexplained or persistent symptoms

  • Differentiate between overlapping autoimmune conditions

  • Monitor immune activity over time

  • Develop more personalized treatment and lifestyle strategies

For many patients, advanced antibody testing can shorten the path to answers and reduce years of uncertainty.

Who Should Consider an Autoimmune Antibody Profile?

This test may be appropriate if you:

  • Have chronic symptoms without a clear diagnosis

  • Have a family history of autoimmune disease

  • Have abnormal or borderline results on initial autoimmune screening tests

  • Are experiencing thyroid, joint, skin, or systemic inflammatory symptoms

  • Want a more comprehensive evaluation of immune system function

Testing can be ordered independently or shared with your healthcare provider for further evaluation.

Simple Testing, Valuable Insight

The Autoimmune Antibody Profile requires a standard blood draw and no special preparation. Results provide a detailed snapshot of immune system activity that can support informed healthcare decisions.

Labs By Request makes advanced testing accessible, transparent, and patient-centered—helping you take an active role in understanding your health.