Description
The Anticardiolipin Antibody (IgM) test measures IgM antibodies directed against cardiolipin, a phospholipid found in cell membranes. These antibodies belong to a group known as antiphospholipid antibodies, which are associated with abnormal blood clotting and may play a role in autoimmune disorders such as Antiphospholipid Syndrome (APS).
Elevated anticardiolipin IgM antibodies may be associated with an increased risk of blood clots, recurrent pregnancy loss, and other vascular complications. When present along with compatible symptoms and other laboratory findings, these antibodies may help support the diagnosis of APS.
Who Should Consider This Test?
This test may be helpful for individuals with:
- Unexplained blood clots
- Deep vein thrombosis (DVT) or pulmonary embolism
- Stroke or transient ischemic attack (TIA), especially at a younger age
- Recurrent miscarriages or pregnancy complications
- Suspected Antiphospholipid Syndrome (APS)
- Systemic lupus erythematosus (SLE) or other autoimmune diseases
- A personal or family history of clotting disorders
Understanding Your Results
Elevated Results
- May indicate the presence of antiphospholipid antibodies
- May be associated with an increased risk of blood clot formation
- May support a diagnosis of APS when combined with clinical findings and other laboratory tests
- Persistent positive results are generally more clinically significant than isolated or temporary elevations
Normal Results
- Suggest that significant levels of anticardiolipin IgM antibodies are not present
- Do not completely exclude APS or other clotting disorders
Because anticardiolipin antibodies can sometimes be temporarily elevated following infections or other illnesses, repeat testing after 12 weeks may be recommended when APS is suspected.
Related Testing
Anticardiolipin IgM is often ordered along with:
- Anticardiolipin IgG and IgA
- Beta-2 Glycoprotein I Antibodies (IgG, IgM, and IgA)
- Lupus Anticoagulant Screen with Reflex Confirmation
Specimen
Blood Draw Required
Fasting Requirements
Fasting is Not Required
