Description
The Antiphospholipid Antibody Panel is a group of blood tests used to detect autoimmune antibodies associated with abnormal clotting and immune system dysfunction.
These antibodies target phospholipids and related proteins in the body and are most commonly used to evaluate antiphospholipid syndrome (APS), an autoimmune condition that increases the risk of blood clots and pregnancy complications.
This panel provides a more complete picture than single antibody testing.
What does the panel include?
Most antiphospholipid panels include:
- Anticardiolipin antibodies (IgG, IgM, ± IgA)
- Beta-2 Glycoprotein I antibodies
- Lupus anticoagulant testing
Together, these markers help assess autoimmune-related clotting risk.
Why is this test important?
Antiphospholipid antibodies are associated with an increased risk of:
- Deep vein thrombosis (DVT)
- Pulmonary embolism
- Stroke or transient ischemic attack (TIA)
- Recurrent pregnancy loss
- Antiphospholipid syndrome (APS)
- Autoimmune conditions such as lupus
These antibodies may be present even when standard clotting tests are normal.
Who should consider this test?
This panel may be helpful for individuals who have:
- Unexplained blood clots
- Recurrent miscarriages
- Early stroke or TIA without clear cause
- Autoimmune disease or lupus
- Family history of clotting disorders
- Persistent inflammation with normal routine labs
- Long COVID or post-viral symptoms
How is this test used?
The antiphospholipid panel is commonly used in evaluations for:
- Suspected antiphospholipid syndrome (APS)
- Autoimmune disease workups
- Recurrent pregnancy loss
- Unexplained clotting disorders
- Advanced inflammation and immune evaluations
Because antibody levels can fluctuate, repeat testing may be recommended if results are positive.
Do I need to fast for this test?
Fasting is not required for the antiphospholipid antibody panel. This test can be performed at any time of day without special preparation.
