Description

Arthritis is defined as inflammation of the joints, and it can be caused by a variety of underlying conditions—including autoimmune diseases, metabolic disorders, and crystal-induced arthritis like gout. Identifying the specific cause of joint pain is critical for determining the most effective treatment, particularly when initiated early.

This comprehensive panel evaluates a core set of biomarkers associated with common types of arthritis such as rheumatoid arthritis, lupus, and gout, while also assessing the level of systemic inflammation.

Ideal for individuals experiencing joint pain or stiffness, this panel serves as a diagnostic starting point and can guide further evaluation if needed.

Included Biomarkers and Tests:

Antinuclear Antibody (ANA) Screen with Reflex to Titer and Pattern

  • Screens for autoantibodies commonly present in systemic autoimmune diseases such as lupus (SLE).
  • Reflexes to titer and pattern if the initial result is positive, helping further define autoimmune activity.

C-Reactive Protein (CRP)

  • An acute-phase protein that rises in response to inflammation.
  • CRP is useful for detecting and monitoring inflammatory activity in the joints and body.

Rheumatoid Factor (RF)

  • A key autoantibody used to help diagnose rheumatoid arthritis (RA).
  • When elevated, RF can support the diagnosis of RA or other autoimmune conditions.

Erythrocyte Sedimentation Rate (ESR)

  • Another non-specific marker of inflammation, often used alongside CRP.
  • Elevated ESR levels suggest ongoing inflammatory processes and can help assess disease activity.

Uric Acid

  • Measures the level of uric acid in the blood.
  • Elevated levels may indicate gout, a form of arthritis caused by uric acid crystal buildup in the joints.

Test Preparation:

  • Fasting: Not required
  • Sample Type: Blood (venipuncture)

Recommended For Individuals With:

  • Ongoing joint pain, stiffness, or swelling
  • Suspected autoimmune arthritis (e.g., RA, lupus) or gout
  • A family history of arthritis or autoimmune conditions
  • Unexplained joint discomfort with no recent injury

Clinical Use Cases:

  • Comprehensive screening for common types of arthritis
  • Identifying inflammatory vs. metabolic causes of joint pain
  • Supporting early diagnosis of autoimmune or crystal-induced arthritis
  • Monitoring systemic inflammation in known joint conditions