Description
The G6PD Quantitative Blood Test measures the activity level of glucose-6-phosphate dehydrogenase (G6PD), an essential enzyme that helps protect red blood cells from damage. A deficiency in this enzyme can lead to hemolytic anemia, especially after exposure to certain foods, infections, or medications.
This test is used to diagnose G6PD deficiency, a common genetic condition, particularly in individuals of African, Mediterranean, Middle Eastern, and Southeast Asian descent.
Purpose of the Test
- Diagnose G6PD deficiency
- Assess cause of unexplained anemia or jaundice
- Identify individuals at risk of hemolytic crisis
- Screen before prescribing certain medications (e.g., sulfa drugs, antimalarials, NSAIDs)
- Determine enzyme status before blood transfusions or surgery
Who Should Consider This Test?
- Individuals with a family history of G6PD deficiency
- Those who have experienced anemia, jaundice, or dark urine after medication or illness
- Individuals from populations with a higher prevalence of the condition
- Patients needing medications known to trigger hemolysis in G6PD-deficient individuals
- Newborns with unexplained jaundice
What the Test Measures
- G6PD Enzyme Activity:
- This test quantifies the level of G6PD in the blood to determine if the individual has normal, low, or absent enzyme activity.
Low or absent G6PD activity may lead to red blood cell destruction under oxidative stress caused by infections, certain foods (like fava beans), or specific medications.
Fasting Required?
No fasting required.
