Description

Assessment of Blood-Brain Barrier Integrity and Neuroimmune Reactivity

The Leaky Brain – Array 20 is a highly specialized test that measures IgG, IgA, and IgM antibodies against critical blood-brain barrier (BBB) proteins—S100B and Claudin-5. These proteins are essential for maintaining the selective barrier that protects the brain from toxins, pathogens, and immune triggers. Breaches in the BBB can be associated with a variety of neurodegenerative, neuroinflammatory, and autoimmune disorders.

Biomarkers Tested:

  • Blood-Brain Barrier Protein IgA
  • Blood-Brain Barrier Protein IgG
  • Blood-Brain Barrier Protein IgM

Each immunoglobulin class helps identify different stages of immune activation and potential chronicity of blood-brain barrier disruption:

  • IgA: Mucosal immune reactivity
  • IgG: Chronic or ongoing immune response

IgM: Recent or acute immune challenge

What This Test Detects:

  • Integrity loss of the blood-brain barrier
  • Immune responses to environmental triggers including:
  • Gut-derived bacterial toxins
  • Amyloid beta proteins
  • Toxic chemicals
  • Food antigens
  • Pathogens (viral, bacterial, fungal)
  • Immune activation due to traumatic brain injuries (e.g., concussions, sports-related trauma)
  • Early signs of neuroautoimmunity or neurodegenerative processes

Developed by a Leader in Functional Immunology:

This test was developed, published, and patented by Aristo Vojdani, PhD, MSc, CLS, widely recognized as the "Father of Functional Immunology." His work in this area spans more than a decade (2012–2024), advancing our understanding of the gut-brain-immune connection.

Who Should Consider This Test?

  • Individuals with chronic neurological symptoms (brain fog, memory loss, cognitive decline)
  • Patients with autoimmune conditions
  • Athletes or individuals with a history of concussions or brain trauma
  • Those with suspected leaky gut or chronic systemic inflammation
  • People with suspected chemical or environmental sensitivity

Clinical Relevance:

Disruption of the blood-brain barrier can lead to increased brain vulnerability to immune cells, pathogens, and toxins. Identifying such breaches early allows for more targeted strategies to address:

  • Neuroinflammation
  • Autoimmune reactivity
  • Cognitive decline and neurodegeneration

Sample Type:

  • Serum (Blood draw)
  • No fasting required unless combined with other tests.