Description

This test kit can be shipped directly to your home and collected in the comfort of your own space.

MethylDetox Profile: Genetic Insight into Methylation and Detoxification Pathways

The MethylDetox Profile evaluates key genetic variants involved in the methylation detoxification pathway and homocysteine metabolism. These pathways play a crucial role in DNA synthesis and repair, detoxification, neurotransmitter regulation, and cardiovascular health. Variations in the genes tested may contribute to a range of chronic health issues such as cardiovascular disease, neurodegenerative disorders, mood imbalances, and impaired detoxification.

This is the swab version of the test, making sample collection simple, non-invasive, and convenient.

Biomarkers and Their Functional Importance

  • AHCY (Adenosylhomocysteinase):
  • Enzyme that converts S-adenosylhomocysteine to homocysteine, a critical step in methylation. Variations can lead to elevated homocysteine, increasing cardiovascular and neurological risk.
  • COMT (Catechol-O-Methyltransferase):
  • Enzyme responsible for the breakdown of catecholamines (dopamine, norepinephrine, epinephrine). Genetic variants can affect mood regulation, stress response, and detoxification capacity.
  • MTHFR (Methylenetetrahydrofolate Reductase):
  • Central enzyme in folate metabolism and methyl group production. Common variants (e.g., C677T, A1298C) can reduce methylation efficiency, leading to elevated homocysteine and increased risk for vascular, neurological, and psychiatric conditions.
  • MTR (Methionine Synthase):
  • Enzyme that converts homocysteine to methionine using vitamin B12. Variants may disrupt this process, resulting in impaired methylation and detoxification.
  • MTRR (Methionine Synthase Reductase):
  • Regenerates active MTR enzyme. Mutations can reduce methylation recycling efficiency, impacting DNA synthesis and repair.

Why This Test Matters

  • Identify Genetic Risk Factors: Detecting variants in methylation genes allows personalized interventions targeting nutrient supplementation and lifestyle modifications to improve methylation efficiency.
  • Support Cardiovascular Health: Elevated homocysteine from genetic variants is a known risk factor for heart disease and stroke.
  • Neurocognitive & Mood Support: Impaired methylation may contribute to depression, anxiety, cognitive decline, and other neurological disorders.
  • Optimize Detoxification: Methylation is vital for phase II liver detoxification; understanding genetic variations helps guide detox strategies.
  • Guide Nutritional Therapy: Personalized recommendations for folate, B12, B6, and other cofactors can be developed based on genetic findings.

Sample Collection & Testing

  • Sample Type: Buccal swab (cheek swab) — quick, painless, and convenient for patients.
  • No fasting or special preparation required.
  • This test kit can be shipped directly to your home and collected in the comfort of your own space.
  • Results typically available within 2–3 weeks.

Who Should Consider the MethylDetox Profile?

  • Individuals with family or personal history of cardiovascular disease, stroke, or elevated homocysteine levels.
  • Patients experiencing neurological or psychiatric symptoms such as depression, anxiety, or cognitive issues.
  • Those with chronic fatigue, fibromyalgia, or unexplained chronic conditions where impaired methylation may play a role.
  • Anyone interested in personalized nutrition and detoxification optimization based on their genetic makeup.

The MethylDetox Profile offers vital genetic insight into methylation and detox pathways, enabling targeted, root-cause-focused interventions to support long-term health and prevent chronic disease.