Description

Why Order This Test?

If you’ve experienced multiple miscarriages, unexplained infertility, or have a personal or family history of blood clots, this comprehensive panel helps uncover possible underlying causes. It includes specialized testing for:

  • Lupus anticoagulant and antiphospholipid syndrome (APS)
  • Inherited clotting disorders (thrombophilias)
  • Autoimmune disease markers
  • Genetic mutations linked to pregnancy loss

This is one of the most complete blood panels available for women or couples seeking answers after pregnancy complications.

What’s Included

This panel screens a wide range of markers across three core areas of risk:

Clotting Function & Lupus Anticoagulant Testing

These tests check for lupus anticoagulants and other abnormalities that can interfere with normal clotting and are linked to miscarriage and APS.

  • Lupus Anticoagulant – PTT-LA
  • Measures clotting time sensitive to lupus anticoagulants.
  • Russell Viper Venom Time (DRVVT)
  • A highly specific test to confirm the presence of lupus anticoagulants.
  • Lupus Anticoagulant Interpretation
  • Expert review combining all clotting test results for a complete interpretation.

Inherited Thrombophilia Markers

These blood proteins and genetic mutations can cause your body to form clots more easily, increasing the risk of miscarriage and pregnancy complications.

  • Antithrombin III Activity
  • Low levels increase the risk of dangerous clot formation.
  • Protein C Activity
  • A deficiency in this natural anticoagulant increases clotting risk.
  • Protein S Activity
  • Works with Protein C; low levels are linked to thrombosis and pregnancy loss.
  • Activated Protein C (APC) Resistance
  • Screens for inherited resistance, often due to Factor V Leiden mutation.
  • Prothrombin Gene Mutation (G20210A)
  • A common genetic variant that increases clotting tendency and pregnancy risks.

Autoimmune & Antiphospholipid Syndrome (APS) Markers

Autoantibodies can attack your own tissues and increase clotting. These are crucial to rule out APS, a major cause of miscarriage.

  • Anticardiolipin Antibodies (IgG, IgM, IgA)
  • Measures all three types of this important APS marker.
  • Beta-2 Glycoprotein 1 Antibodies (IgG & IgM)
  • High specificity test for APS-related clotting issues.
  • Phosphatidylserine/Prothrombin Antibodies
  • Additional markers linked to autoimmune clotting conditions.
  • Antinuclear Antibodies (ANA)
  • Screens for underlying autoimmune diseases like lupus (SLE), which can lead to pregnancy loss.

Other Risk Marker

  • Homocysteine
  • Elevated homocysteine levels are linked to blood vessel damage and an increased risk of clotting and miscarriage. Often associated with MTHFR mutation.

Test Details

  • Sample Type: Blood test
  • Fasting Required: No fasting required

Who Should Take This Test?

This panel is ideal for:

  • Women who have experienced two or more miscarriages
  • Individuals undergoing IVF or fertility treatment
  • Those with a personal or family history of blood clots
  • People diagnosed with or suspected of having autoimmune disorders
  • Couples with unexplained infertility