Description
The Neurofilament Light Chain (NfL) Plasma Test measures levels of NfL protein in the blood. NfL is a structural protein found in neurons, and elevated levels in plasma can indicate nerve cell damage or neurodegeneration.
Purpose of the Test
- Detect neurodegeneration: Elevated NfL can signal neuronal injury, even before symptoms appear.
- Monitor disease progression: Useful in conditions like multiple sclerosis (MS), Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS).
- Assess treatment response: Can help clinicians evaluate the effectiveness of therapies targeting neurodegeneration.
- Research and clinical trials: Increasingly used as a biomarker in neurological studies.
Clinical Significance
- Higher NfL levels: May indicate active nerve damage, inflammation, or neurodegenerative disease.
- Lower or normal levels: Suggest stable neuronal health.
Test Details
- Sample: Plasma (blood draw)
- Preparation: Fasting not required
- Interpretation: NfL levels should always be considered alongside clinical evaluation and other diagnostic tests, as levels can rise due to age, trauma, or other medical conditions.
This test is particularly valuable for early detection and monitoring of neurological conditions, providing insight into neuronal injury before significant functional decline occurs.
