Description

Advanced Metabolic & Functional Assessment- Shipping nationwide

The OAp™ Organic Acids Profile is a comprehensive urine-based test that offers a detailed evaluation of over 75 metabolic markers to assess gut health, mitochondrial function, neurotransmitter metabolism, detoxification pathways, oxidative stress, and essential nutrient status.

This test offers deep insight into how the body is functioning at a cellular and biochemical level, helping to uncover functional imbalances even when blood tests appear normal.

This test is not available for individuals under 12 years of age.

Shipping & Processing

  • Shipping Time: 2–3 Business Days (Nationwide)
  • Sample Processing Time: 14 Business Days
  • Specimen Type: First morning urine (collected at home and frozen)

Sample Preparation & Collection

Preparation:

  • Avoid fruits, jams, and jellies for 48 hours prior to sample collection.
  • Continue medications and supplements unless otherwise directed by your provider.

Collection Steps:

  1. Empty your bladder before bed (do not collect this sample).
  2. Collect your first urine upon waking (15–50 mL).
  3. Freeze sample for at least 2 hours before shipping.
  4. Complete and include the test requisition form.

Biomarker Categories & What They Reveal

Mitochondrial Function & Energy Production

  • Citric Acid, Isocitric Acid, Succinic Acid, Fumaric Acid, Malic Acid, a-Ketoglutaric Acid: Key intermediates in the Krebs (TCA) cycle. Imbalances may suggest mitochondrial dysfunction or fatigue-related issues.
  • Pyruvic Acid, Lactic Acid: Indicators of anaerobic metabolism, possibly due to oxygen deficiency or nutrient insufficiency (e.g., B-vitamins).

Neurotransmitter Metabolism

  • 5-HIAA, HVA, VMA, Quinolinic Acid, Kynurenic Acid: Reflect serotonin, dopamine, norepinephrine, and tryptophan metabolism. Imbalances may be linked to mood disorders, ADHD, anxiety, or sleep problems.
  • Quinolinic/Kynurenic Ratio, HVA/VMA Ratio: Evaluate neuroinflammation and excitatory vs. calming neurotransmitter activity.

Detoxification & Oxidative Stress

  • Glucaric Acid, Pyroglutamic Acid, Sulfate, Orotic Acid: Reflect liver detoxification pathway efficiency.
  • 8-OHdG: A marker of oxidative DNA damage.
  • Hippuric Acid, Benzoic Acid, Mandelic Acid: Suggest exposure to environmental toxins, solvents, or preservatives.

Gut Health & Dysbiosis

  • D-Lactic Acid, Arabinitol, Tartaric Acid: Associated with bacterial and yeast/fungal overgrowth (e.g., Candida).
  • 3-Indoleacetic Acid, Phenylacetic Acid: Reflect intestinal microbial metabolism and gut-derived toxins.

Fatty Acid & Amino Acid Metabolism

  • Methylsuccinic Acid, Hexanoylglycine, Suberic Acid, Adipic Acid: Indicators of fatty acid oxidation disorders or mitochondrial overload.
  • Total BCKAs, a-Keto acids (e.g., a-Ketoisocaproic, a-Ketoisovaleric): Evaluate branched-chain amino acid metabolism and protein catabolism.

Nutrient Deficiencies

  • MMA (Methylmalonic Acid): Highly specific marker for Vitamin B12 deficiency.
  • Pyridoxic Acid: Reflects Vitamin B6 status.
  • Formiminoglutamic Acid (FIGLU): Suggests folate deficiency.
  • Xanthurenic Acid, Kynurenic Acid: Tied to Vitamin B6 or B3 metabolism.
  • Phosphate: May correlate with energy metabolism or kidney function.

Hormone & Adrenal Markers

  • Cortisol, Cortisone, Cortisol/Cortisone Ratio: Adrenal function and stress response markers.
  • Aldosterone: Regulates sodium, potassium, and fluid balance.

Others of Clinical Relevance

  • Glucose & Fructose: Reveal sugar metabolism or malabsorption.
  • Equol: Metabolite of soy isoflavones – may be relevant in estrogen metabolism.
  • Creatinine: Used to normalize all urinary analytes.

What You Get With the Report

  • Expanded Summary Page tailored to your individual results
  • Algorithm-driven nutrient & lifestyle recommendations
  • Visual mapping of disrupted metabolic pathways
  • Insights into nutritional deficiencies, yeast overgrowth, bacterial imbalance, mitochondrial stress, detoxification burden, and neurochemical imbalances
  • Personalized notes and guidance for healthcare providers to develop a targeted action plan

Who Should Get the OAp Organic Acids Profile?

This test is ideal for individuals experiencing:

  • Chronic fatigue or low energy
  • Brain fog, memory issues, or mood swings
  • Sleep disturbances or anxiety/depression
  • Digestive symptoms like bloating, gas, or irregular bowel movements
  • Unexplained nutrient deficiencies
  • Yeast or candida overgrowth symptoms
  • Detox issues or high toxin exposure (e.g., mold, chemicals)
  • Poor exercise recovery or mitochondrial disorders
  • Neurological symptoms or behavioral disorders (ADHD, autism, etc.)

It’s especially powerful when used alongside GI testing, nutrient panels, or environmental toxin profiles for a more complete functional health picture.