Description
The ASCA (Anti-Saccharomyces Cerevisiae Antibodies) IgG and IgA Blood Test detects antibodies against Saccharomyces cerevisiae, a type of yeast commonly found in the gut. Elevated ASCA antibodies are often associated with Crohn’s disease and can help distinguish it from ulcerative colitis and other gastrointestinal disorders.
This test provides insight into autoimmune activity in the digestive tract and may support diagnosis and disease management in patients with inflammatory bowel disease (IBD).
Purpose of the Test
- Assist in the diagnosis of Crohn’s disease
- Differentiate Crohn’s disease from ulcerative colitis
- Evaluate autoimmune activity in the gut
- Monitor disease progression or response to treatment
- Support comprehensive gastrointestinal panels for undiagnosed symptoms
Who Should Consider This Test?
- Individuals with chronic diarrhea, abdominal pain, or unexplained GI symptoms
- Patients with suspected inflammatory bowel disease (IBD)
- People with a family history of Crohn’s disease or ulcerative colitis
- Individuals undergoing diagnostic workup for autoimmune gastrointestinal disorders
- Patients being monitored for treatment response in Crohn’s disease
What the Test Measures
- ASCA IgG Antibodies: Indicates long-term immune response to Saccharomyces cerevisiae
- ASCA IgA Antibodies: Indicates mucosal immune response in the gastrointestinal tract
Elevated IgG and/or IgA levels may suggest Crohn’s disease or increased autoimmune activity in the gut. Normal levels do not rule out IBD entirely but may help in differential diagnosis.
Fasting Required?
No fasting required.
