Description

The Saliva Steroid LCMS Profile 23 is a comprehensive hormone panel that analyzes 18 endogenous steroid hormones and includes markers for melatonin, synthetic estrogens, and medications that affect hormone pathways (e.g., aromatase and 5α-reductase inhibitors). Utilizing liquid chromatography-mass spectrometry (LC-MS/MS), this test offers highly sensitive, precise measurement of hormone levels from a simple at-home saliva sample.

This profile is ideal for identifying hormone imbalances, monitoring HRT (hormone replacement therapy), or detecting the influence of exogenous hormone medications.

At-home saliva collection kit

Nationwide shipping (USA)

LC-MS/MS precision technology

Who Should Consider This Test?

This test is recommended for individuals who:

  • Are on or considering bioidentical or synthetic hormone therapy
  • Want a non-invasive, accurate measure of steroid hormone levels
  • Have symptoms related to hormonal imbalance, such as fatigue, weight changes, mood swings, low libido, or insomnia
  • Are experiencing PMS, perimenopause, menopause, or andropause
  • Suspect exposure to or use of synthetic hormones or hormone-blocking medications
  • Need a more advanced hormone test than standard saliva or serum panels

How This Test Can Help

  • Measure actual bioavailable hormone levels active at tissue level
  • Evaluate the impact of HRT, contraceptives, or anti-hormone medications
  • Assess cortisol and cortisone balance for stress-related hormone dysregulation
  • Detect synthetic estrogens (e.g., ethinyl estradiol) and inhibitors like finasteride or anastrozole
  • Provide insights for functional medicine, endocrinology, and integrative therapy plans

Biomarkers Included

Steroid Hormones

  • 11-Deoxycortisol – Precursor to cortisol; helps assess adrenal function
  • 17-Hydroxyprogesterone – Key precursor to cortisol and sex steroids
  • Aldosterone – Regulates salt/water balance and blood pressure
  • Allopregnanolone – Neuroactive steroid that influences mood, sleep, and stress
  • Androstenedione – Precursor to testosterone and estrogens
  • Corticosterone – Adrenal hormone involved in the stress response
  • Cortisol – Primary stress hormone; evaluated for adrenal fatigue, anxiety, or insomnia
  • Cortisone – Inactive form of cortisol; helps assess cortisol metabolism
  • DHEA – Adrenal hormone supporting energy, mood, and hormone production
  • DHEA-S – Sulfated form of DHEA with a longer half-life
  • DHEA/7-Keto DHEA Ratio – Assesses balance between active and metabolized DHEA
  • DHT (Dihydrotestosterone) – Potent androgen linked to libido and hair loss
  • E1 (Estrone) – A weaker estrogen, more prevalent post-menopause
  • E2 (Estradiol) – The dominant estrogen in premenopausal women
  • E3 (Estriol) – A protective, weaker estrogen

Synthetic Hormones & Inhibitors

  • Ethinyl Estradiol – Synthetic estrogen found in oral contraceptives
  • Anastrozole – Aromatase inhibitor used to block estrogen production
  • Letrozole – Another aromatase inhibitor used in hormone-sensitive cancers or fertility
  • Finasteride – 5α-reductase inhibitor used for hair loss or prostate conditions

Other Hormonal Markers

  • Melatonin – Sleep hormone; essential for circadian rhythm regulation
  • Pregnenolone Sulfate – Precursor to multiple steroid hormones
  • Progesterone – Balances estrogen, supports mood, menstrual regularity, and sleep
  • Testosterone – Key androgen affecting libido, muscle mass, mood, and energy
  • Pg/E2 Ratio – Evaluates the balance between progesterone and estradiol

Specimen Type

  • Saliva Collection
  • Collected at home using provided tubes and instructions
  • Multiple time-point collection may be recommended depending on provider guidance

Key Details

  • Test Type: At-home saliva hormone panel
  • Collection Method: Self-collected saliva samples
  • Shipping: Nationwide (USA) – Includes pre-paid return label