Description
Testosterone replacement therapy (TRT) is commonly used to address low testosterone levels, often referred to as Low T. Ongoing monitoring is essential to ensure treatment is effective and to reduce the risk of potential complications. One of the primary concerns with TRT is the development of polycythemia (an increase in red blood cells), along with possible adverse effects on cholesterol and triglyceride levels. Regular laboratory testing allows healthcare providers to maintain optimal testosterone levels while minimizing these risks.
Tests Included in the Panel
Complete Blood Count (CBC) The CBC measures red blood cells, white blood cells, platelets, and hemoglobin. It helps detect polycythemia, a potential side effect of testosterone therapy. Elevated red blood cell levels can increase the risk of blood clots, stroke, and other cardiovascular complications, making routine monitoring essential.
Comprehensive Metabolic Panel (CMP) This panel evaluates kidney and liver function, blood glucose levels, and electrolyte balance. Monitoring these markers helps ensure the body is safely processing testosterone therapy and that vital metabolic and organ functions remain within normal ranges.
Estradiol Testosterone can be converted into estradiol, a form of estrogen, particularly at higher doses. Elevated estradiol levels may lead to side effects such as gynecomastia or fluid retention. Measuring estradiol helps ensure hormonal balance and supports appropriate adjustments to therapy.
Lipid Panel Testosterone replacement may influence cholesterol and triglyceride levels. The lipid panel measures total cholesterol, HDL (good cholesterol), LDL (bad cholesterol), and triglycerides. Tracking these values helps assess cardiovascular risk and identify unfavorable lipid changes associated with therapy.
Free and Total Testosterone Total testosterone reflects the overall amount of testosterone in the bloodstream, while free testosterone represents the biologically active portion available to tissues. Monitoring both provides a more complete picture of hormone status and helps ensure levels remain within the therapeutic range.
SHBG (Sex Hormone–Binding Globulin) SHBG is a protein that binds testosterone and determines how much hormone is available in its active form. Measuring SHBG improves interpretation of testosterone results and helps explain persistent symptoms when total testosterone appears normal. Including SHBG supports more precise and individualized TRT management.
Fasting
Fasting is recommended for this panel.
Why Monitoring Is Important
Reducing Risk: Routine monitoring helps prevent complications such as polycythemia, elevated estradiol levels, and adverse changes in cholesterol and triglycerides.
Optimizing Therapy: By evaluating testosterone, SHBG, and related biomarkers, providers can fine-tune dosing to achieve symptom improvement while maintaining cardiovascular and metabolic health.
This comprehensive panel supports safe, effective testosterone replacement therapy by providing the insights needed to balance benefits with long-term health considerations.
