Description

The TOXDetect Profile is a comprehensive urine-based laboratory assessment designed to evaluate your body’s burden of specific environmental toxins and synthetic chemicals. This test screens for metabolites of common pollutants such as herbicides, insecticides, plasticizers (phthalates), solvents, and endocrine disruptors.

Environmental exposure to these substances has been associated with a wide range of acute and chronic health issues, including hormonal imbalances, neurological symptoms, immune dysfunction, fatigue, infertility, developmental disorders, and even some cancers.

This panel is ideal for individuals with suspected chemical sensitivity, unexplained chronic symptoms, or frequent exposure to industrial or environmental toxins.

Why This Test Is Important

Environmental toxins are increasingly recognized as contributors to chronic illness. This test helps to:

  • Identify hidden exposures to everyday chemicals that can contribute to or worsen symptoms
  • Provide a personalized chemical exposure profile for more effective treatment planning
  • Monitor detoxification progress during chelation, environmental medicine, or lifestyle detox programs
  • Evaluate occupational exposure risks for those working in agriculture, manufacturing, hair salons, construction, etc.

Symptoms and Conditions Potentially Linked to Toxic Burden

Patients who may benefit from this test often present with symptoms such as:

  • Fatigue and brain fog
  • Hormonal imbalances (e.g., estrogen dominance, low testosterone)
  • Skin rashes or sensitivities
  • Infertility or irregular menstruation
  • Headaches or migraines
  • Sleep disturbances
  • Autoimmune or neurodegenerative conditions
  • Poor detoxification or liver dysfunction
  • Suspected mold or chemical sensitivity

Biomarkers Measured

This test evaluates 21 environmental biomarkers, grouped by chemical class:

1. Herbicides and Pesticide Metabolites

  • 2,4-D – A common herbicide used in weed control
  • 3PBA (3-Phenoxybenzoic Acid) – Pyrethroid insecticide metabolite
  • 2-3-4-MHA – Xylene metabolite, found in paint and industrial solvents

2. Plasticizers & Phthalates

Phthalates are synthetic chemicals used in plastics, cosmetics, and household items. They act as endocrine disruptors.

  • DEP (Diethyl Phthalate)
  • DPP (Di-n-propyl Phthalate)
  • Monobutyl Phthalate
  • Monoethyl Phthalate
  • Monoisobutyl Phthalate
  • MEHP (Mono-2-ethylhexyl Phthalate)
  • MEOHP (Mono-2-ethyl-5-oxohexyl Phthalate)

3. Solvent & Petrochemical Metabolites

  • HEMA (2-Hydroxyethyl Methacrylate) – Found in resins and dental materials
  • Phenylglyoxylic Acid – Styrene metabolite, commonly used in plastic manufacturing

4. Endocrine Disruptors

  • Bisphenol S (BPS) – BPA substitute still associated with hormone disruption

5. N-Acetyl Conjugates (Solvent Exposure Biomarkers)

Used to assess breakdown products of volatile organic compounds (VOCs):

  • NACE
  • NADB
  • NAE
  • NAP
  • NAPR

6. Other Toxins

  • Perchlorate – Disrupts iodine uptake in the thyroid, potentially affecting thyroid hormone production

Sample Collection & Instructions

Sample Type: First morning urine

Turnaround Time: 10 business days (excluding shipping time)

Fasting Required: No

Collection Method: At-home collection kit

Important Pre-Collection Instructions:

  • Do NOT collect while menstruating
  • Avoid these medications for 4 days before collection:
  • Cephalexin
  • Cefalexin
  • Keflex
  • Bio-Cef
  • Novo-Lexin
  • Collect your first urine sample immediately upon waking
  • Do NOT eat or drink before sample collection

Samples must be returned promptly and should only be shipped Monday through Friday to avoid delays.

Who Should Consider This Test

This test is appropriate for:

  • Individuals with chemical sensitivities or multiple unexplained symptoms
  • Patients with chronic fatigue, fibromyalgia, or autoimmune disorders
  • People with occupational exposure to industrial or agricultural chemicals
  • Individuals undergoing a detox or environmental medicine program
  • Anyone concerned with long-term health risks from environmental toxins

Benefits of Testing

  • Gain actionable insight into your environmental exposure
  • Detect hidden contributors to chronic illness
  • Guide targeted detoxification strategies
  • Help prevent long-term damage from toxin accumulation