Description

Track your body’s natural sleep-wake cycle and stress rhythm with this four-point diurnal hormone profile.

The UDH II profile is a non-invasive, at-home urine test that evaluates the diurnal (daily) fluctuations of cortisol, cortisone, and melatonin. These three hormones are key regulators of your circadian rhythm, stress response, and sleep-wake cycle. This test is ideal for individuals struggling with insomnia, fatigue, burnout, jet lag, adrenal dysfunction, or mood changes tied to sleep disruption.

At-home urine collection kit shipped nationwide

What This Test Measures

Samples are collected at four key timepoints during the day: morning, noon, evening, and night, allowing for a full picture of how your hormone rhythms are performing.

Cortisol (4 Points)

Cortisol is your primary stress hormone, naturally highest in the morning and lowest at night. A healthy cortisol curve supports energy, focus, metabolism, and immune function.

  • Cortisol – Morning
  • Cortisol – Noon
  • Cortisol – Evening
  • Cortisol – Night

Cortisone (4 Points)

Cortisone is the inactive form of cortisol and gives insight into how your body converts, clears, and regulates cortisol throughout the day.

  • Cortisone – Morning
  • Cortisone – Noon
  • Cortisone – Evening
  • Cortisone – Night

Melatonin (4 Points)

Melatonin is the hormone that tells your body it’s time to rest and recover. Low or mistimed melatonin can contribute to difficulty falling asleep, frequent waking, or excessive daytime fatigue.

  • Melatonin – Morning
  • Melatonin – Noon
  • Melatonin – Evening
  • Melatonin – Night

Control Marker

  • Creatinine – Ensures proper sample concentration and test accuracy

Who Should Consider This Test?

This profile is recommended for individuals experiencing:

  • Trouble falling or staying asleep
  • Chronic fatigue or burnout
  • Irregular sleep/wake patterns (e.g., shift workers, travelers)
  • Suspected adrenal dysfunction or HPA axis imbalance
  • Mood disorders that worsen with poor sleep
  • Brain fog or difficulty waking up refreshed

Test Overview

  • Test Type: Urine (4 timepoints)
  • Collection Method: At-home kit
  • Shipping: Nationwide (USA)