Description
Non-Invasive Genetic Testing for Methylation and Neurotransmitter Function
This test detects variations (SNPs) in the COMT (Catechol-O-Methyltransferase) gene, which plays a crucial role in breaking down neurotransmitters like dopamine, epinephrine, and norepinephrine—as well as metabolizing estrogen and catechols involved in detoxification.
Understanding your COMT genotype can help personalize approaches to:
- Mood and anxiety support
- Estrogen metabolism
- Stress response
- Methylation balance
- Supplementation with methyl donors (like methylfolate or SAMe)
Swab-Based Collection – No Blood Draw Required
This version of the COMT test uses a simple cheek swab for DNA collection—ideal for those seeking a non-invasive, at-home testing option.
Why It Matters:
- Certain COMT variants can lead to slower or faster breakdown of neurotransmitters and estrogens
- Can influence your response to methylated B vitamins, adaptogens, and detox protocols
- Provides valuable insight for those with MTHFR, hormone imbalances, anxiety, or fatigue
Test Info:
- Sample type: Buccal (cheek) swab
- Fasting: Not required
- Shipping: Nationwide availability

