Description

A plasma neurofilament light chain (pNfL) blood test measures the amount of a protein in your blood that indicates neuronal damage. This test can help assess and monitor neurodegenerative diseases, such as multiple sclerosis (MS), Alzheimer's disease, and amyotrophic lateral sclerosis (ALS).

  • Elevated NfL levels may indicate damage to neurons, such as: 
  • Multiple sclerosis (MS) 
  • Amyotrophic lateral sclerosis (ALS) 
  • Alzheimer's disease 
  • Traumatic brain injury 
  • Normal NfL levels do not rule out the possibility of neurodegenerative disease. 

Interpretation: 

  • NfL levels can vary depending on the underlying cause of neuronal damage. 
  • High NfL levels may require further investigation to determine the cause and extent of nerve damage. 
  • NfL levels can also be used to monitor disease progression and treatment effectiveness. 

Additional Information: 

  • The NfL test is not a diagnostic test, but a biomarker that can help identify potential neurodegenerative conditions. 
  • Other factors, such as age, symptoms, and medical history, should also be considered when interpreting NfL results. 
  • It is important to consult with a healthcare professional for proper interpretation of NfL test results and to discuss any potential treatment options. 

Fasting not required.