Description

The Neurotransmitters + Saliva Steroids Profile offers a detailed analysis of neurochemical and hormonal balance, helping uncover the root causes of a wide range of mood, cognitive, and behavioral symptoms. This dual-panel test evaluates both urinary neurotransmitters and salivary steroid hormones to assess how the brain and endocrine systems may be interacting.

This comprehensive profile is commonly used to investigate issues such as anxiety, depression, insomnia, chronic stress, ADD/ADHD, mood swings, and fatigue.

At-home collection kit

Nationwide shipping (USA)

Urine + Saliva specimens

Who Should Consider This Test?

This test is ideal for individuals experiencing:

  • Mood disorders (anxiety, depression, irritability)
  • Chronic stress, burnout, or adrenal fatigue
  • ADD/ADHD or other attention and focus issues
  • Difficulty sleeping, staying asleep, or waking unrested
  • Hormone-related mood changes (PMS, PMDD, menopause)
  • Low motivation, poor memory, or brain fog

How This Test Can Help

  • Identify neurotransmitter imbalances contributing to emotional or cognitive symptoms
  • Evaluate the relationship between adrenal function and brain chemistry
  • Detect low dopamine, serotonin, or GABA, which may be involved in anxiety, depression, and sleep issues
  • Assess stress hormone patterns (cortisol, DHEA, progesterone, testosterone, estrogen)
  • Support personalized treatment plans including supplements, lifestyle, or medication

Biomarkers Included

Urinary Neurotransmitters

These markers assess the functional status of key brain chemicals that influence mood, sleep, focus, energy, and more.

  • Dopamine – Motivation, reward, attention
  • DOPAC – Dopamine metabolite
  • HVA (Homovanillic Acid) – Another dopamine breakdown product
  • Serotonin – Mood balance, sleep, pain sensitivity
  • 5-HIAA – Serotonin metabolite
  • GABA – Calming, anti-anxiety neurotransmitter
  • Glutamate – Excitatory neurotransmitter linked to learning and anxiety
  • Glutamine – Precursor to GABA and glutamate
  • Histamine – Alertness, inflammation, anxiety
  • N-Methylhistamine – Histamine metabolite
  • Histidine – Precursor to histamine
  • Norepinephrine – Focus, stress response
  • Epinephrine – Fight-or-flight response, energy
  • NE/Epi Ratio – Evaluates balance between norepinephrine and epinephrine
  • Normetanephrine – Norepinephrine metabolite
  • PEA (Phenylethylamine) – Focus, mood, attention
  • Taurine – Neuromodulator that supports GABA activity
  • Tryptophan – Precursor to serotonin
  • Tyrosine – Precursor to dopamine and norepinephrine
  • Tyramine – Affects catecholamine release
  • VMA (Vanillylmandelic Acid) – Final metabolite of norepinephrine/epinephrine
  • 3-Hydroxykynurenine, Kynurenic Acid, Kynurenine, Xanthurenic Acid – Tryptophan metabolites involved in inflammation and serotonin pathways
  • Creatinine – Used to normalize urine concentrations

Salivary Steroid Hormones

These hormones impact mood, energy, stress resilience, reproductive health, and metabolic balance.

  • Cortisol – Main stress hormone; dysregulation can cause anxiety, fatigue, or insomnia
  • DHEA-S – Adrenal hormone supporting energy, mood, and hormone balance
  • Progesterone – Calming hormone that supports GABA function; deficiency linked to PMS, anxiety
  • Testosterone – Motivation, energy, libido; imbalance can affect mood and muscle mass
  • E2 (Estradiol) – Primary estrogen; affects serotonin levels, cognition, and menstrual cycles

Specimen Type

  • Urine: Collected at home using a first-morning or 24-hour sample
  • Saliva: Collected at multiple time points (per kit instructions)

Key Details

  • Test Type: At-home urine + saliva collection
  • Collection Method: Self-collection kit shipped to your home
  • Shipping: Nationwide (USA) – Prepaid return shipping included