Description

The SLCO1B1 genotype is a genetic factor that can increase the risk of statin-induced myopathy. The SLCO1B1 gene encodes a protein that helps the liver remove statins from the body. 

SLCO1B1 genotypes associated with statin-induced myopathy

  • rs4149056
  • The C allele of this SNP is associated with an increased risk of myopathy. The *5 allele (Val174Ala) is a loss-of-function allele that increases statin concentrations in the blood. 
  • SLCO1B1-poor function
  • This genotype is associated with a high risk of myopathy, especially with simvastatin. 

Recommendations for statin therapy based on SLCO1B1 genotype 

  • Consider an alternative statin
  • Limit the dose of simvastatin to less than 20 mg per day
  • Avoid the 80 mg dose of simvastatin unless it's been tolerated for 12 months
  • Consider a lower dose of simvastatin

Other factors that affect statin-induced myopathy statin dose, age, drug interactions, and comorbidities. 

Symptoms of statin-induced myopathy include muscle pain, weakness, and fatigue. 

Test takes 14 business days not including transportation time. Fasting not required.